Clinical Efficacy of Xuefuzhuyu Oral Liquid in the Treatment of Lupus Nephritis and Its Effect on Immunological Indexes
Objective To investigate the clinical efficacy of Xuefuzhuyu Oral Liquid in the treatment of lupus nephritis,and its effect on immunological indicators.Methods Sixty patients with lupus nephritis admitted to the Second Affiliated Hospital of Hebei North University from October 2021 to October 2022 were selected and divided into the control group and the observation group by the random number table method,with 30 cases in each group.The patients in the two groups were given conventional medication treatment,on this basis,the patients in the observation group were additionally treated with Xuefuzhuyu Oral Liquid.Both groups were treated for three months.Results After treatment,the systemic lupus erythematosus disease activity index(SLEDAI)score,the levels of white blood cell count(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),24 h urine protein quantification,urine red blood cell count,blood creatinine(SCr),blood urea nitrogen(BUN),immunoglobulin A(IgA),immunoglobulin G(IgG),and the CD8 + T cells and the percentage of T follicular helper cells(Tfh)in the observation group were significantly lower than those in the control group(P<0.05),while the levels of complement C3,albumin(Alb),and thymosin β4,the percentage of active E rosette-forming cells,lymphocyte count,CD4 + T cell and CD4 +/CD8 + in the observation group were significantly higher than those in the control group(P<0.05).The incidence of anti-double stranded DNA antibody positivity in the two groups was significantly lower than those before treatment(P<0.05),but there was no statistically significant difference between the two groups.The incidence of infection in the observation group was significantly lower than that in the control group(3.33%vs.26.67%,P<0.05),and the total effective rate in the observation group was significantly higher than that in the control group(86.67%vs.63.33%,P<0.05).The total incidence of adverse reactions in the observation group was comparable to that in the control group(6.67%vs.13.33%,P>0.05).Pearson correlation analysis showed that thymosin β4 level was negatively correlated with SLEDAI score,WBC,ESR,CRP,24 h urine protein quantification,urine red blood cell count,SCr,BUN,IgA,IgG,CD8 + T cells,and percentage of Tfh cells(r =-0.729,-0.418,-0.674,-0.785,-0.651,-0.512,-0.684,-0.676,-0.499,-0.513,-0.624,-0.631,P<0.05),while it was positively correlated with complement C3,Alb,percentage of active E rosette-forming cells,lymphocyte count,CD4 + T cell,and CD4 +/CD8 +(r = 0.475,0.452,0.619,0.626,0.633,0.645,P<0.05).Conclusion Xuefuzhuyu Oral Liquid in the treatment of patients with lupus nephritis has significant clinical efficacy,it can enhance the patient's immune level,improve renal function,reduce the incidence of infection,and promote disease recovery,and its mechanism may be related to Xuefuzhuyu Oral Liquid promoting the synthesis of thymosin β4.
Xuefuzhuyu Oral Liquidthymosinlupus nephritisimmune levelrenal function
万方数据
维普
