Effect of Edaravone and Dexborneol Combined with Butylphthalide and Sodium Chloride Injection on the Expression of Serum Monocyte Chemoattractant Protein-1 and Endothelin-1 in Patients with Acute Cerebral Infarction
Objective To investigate the effect of edaravone and dexborneol combined with Butylphthalide and Sodium Chloride Injection on the expression of serum monocyte chemoattractant protein-1(MCP-1)and endothelin-1(ET-1),and the atherosclerotic plaque in patients with acute cerebral infarction(ACI).Methods A total of 140 patients with ACI admitted to the Handan Hospital of Traditional Chinese Medicine from December 2020 to August 2022 were selected and randomly divided into the combined group and the control group by the random number table method,with 70 cases in each group.The patients in the two groups were given Butylphthalide and Sodium Chloride Injection,on this basis,the patients in the combined group were treated with Edaravone and Dexborneol Injection.Both groups were treated for 14 d.Results The total effective rate in the combined group was 91.43%,which was significantly higher than 68.57%in the control group(P<0.05).After treatment,the carotid intima-media thickness,plaque area,National Institutes of Health Stroke Scale(NIHSS)score,modified Rankin Scale(MRS)score,and the levels of serum MCP-1,ET-1,malondialdehyde(MDA),and superoxide dismutase(SOD)in the two groups significantly reduced(P<0.05),and those in the combined group were significantly lower than those in the control group(P<0.05).During treatment,the incidence of adverse reactions in the combined group was comparable to that in the control group(12.86%vs.14.29%,P>0.05).Conclusion Edaravone and dexborneol combined with Butylphthalide and Sodium Chloride Injection in the treatment of acute cerebral infarction has good clinical efficacy and safety,which can effectively improve the neurological defect,the stability of carotid atherosclerotic plaque and the endothelial function,reduce the oxidative stress level,and improve the quality of life.
acute cerebral infarctionButylphthalide and Sodium Chloride Injectionedaravone and dexborneolmonocyte chemoattractant protein-1endothelin-1oxidative stressatherosclerotic plaque
万方数据
维普
