Objective To study the chemical constituents of Qingwen Hufei Granules.Methods The studies related to the chemical constituents of medicinal materials in Qingwen Hufei Granules were searched from the CNKI,PubMed,Web of Science and other databases.Based on studies and ChemicalBook database,a chemical constituent database was established.The ultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbital trap high-resolution mass spectrometry(UHPLC-Q Exactive Focus MS/MS)method was used to analyze the spectral data of formulations.The molecular formulas were fitted by the Xcalibur 4.0 software and matched with the information of self-built database to preliminarily infer the molecular formula information,and the molecular formulas were compared with the information of ChemicalBook or ChemSpider databases to infer the structures of chemical constituents.Results A total of 158 chemical constituents were identified,including 36 glycosides,29 flavonoids,28 phenylpropanoids,18 organic acids,17 terpenoids,8 chromones and 22 other constituents.Conclusion The established method can systematically,accurately and fastly qualitatively analyze the chemical constituents in Qingwen Hufei Granules.
关键词
清瘟护肺颗粒/超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法/化学成分/结构鉴定
Key words
Qingwen Hufei Granules/ultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbital trap high-resolution mass spectrometry method/chemical constituent/structural identification
维普
万方数据