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清瘟护肺颗粒化学成分研究

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目的 研究清瘟护肺颗粒的化学成分。方法 查阅中国知网、PubMed、Web of Science等数据库，检索该制剂组方药材化学成分的相关文献，结合文献报道和ChemicalBook数据库信息，建立化学成分数据库。采用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-Q Exactive Focus MS/MS)法分析制剂的图谱数据，并以Xcalibur 4。0 软件拟合分子式，与自建数据库信息进行匹配，初步推测分子式信息，与ChemicalBook或ChemSpider数据库比对，推测化学成分结构。结果 共鉴定出 158 个化学成分，包括苷类36 个，黄酮类 29 个，苯丙素类 28 个，有机酸类 18 个，萜类 17 个，色原酮类 8 个，其他类 22 个。结论 所建立的方法可系统、准确、快速地定性分析清瘟护肺颗粒中的化学成分。
Study on the Chemical Constituents of Qingwen Hufei Granules
Objective To study the chemical constituents of Qingwen Hufei Granules.Methods The studies related to the chemical constituents of medicinal materials in Qingwen Hufei Granules were searched from the CNKI,PubMed,Web of Science and other databases.Based on studies and ChemicalBook database,a chemical constituent database was established.The ultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbital trap high-resolution mass spectrometry(UHPLC-Q Exactive Focus MS/MS)method was used to analyze the spectral data of formulations.The molecular formulas were fitted by the Xcalibur 4.0 software and matched with the information of self-built database to preliminarily infer the molecular formula information,and the molecular formulas were compared with the information of ChemicalBook or ChemSpider databases to infer the structures of chemical constituents.Results A total of 158 chemical constituents were identified,including 36 glycosides,29 flavonoids,28 phenylpropanoids,18 organic acids,17 terpenoids,8 chromones and 22 other constituents.Conclusion The established method can systematically,accurately and fastly qualitatively analyze the chemical constituents in Qingwen Hufei Granules.

Qingwen Hufei Granulesultra-high-performance liquid chromatography coupled with quadrupole/electrostatic field orbital trap high-resolution mass spectrometry methodchemical constituentstructural identification

龙凯花、刘静、曹利平、刘满军、刘洋、杜霞、张红

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陕西省中医药研究院,陕西 西安 710003

陕西省中医医院,陕西 西安 710003

清瘟护肺颗粒 超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法 化学成分 结构鉴定

陕西省重点研发计划陕西省重点研发计划秦创原中医药创新研发转化项目"秦药"研发重点实验室项目陕西省科协青年人才托举计划陕西省中医药局项目陕西省西安市科技计划陕西省西安市科技计划曹利平全国名中医传承工作室项目

2022ZDXM-SF-062022SF-2732022-QCYZH-0062021-QYPT-001202303212021-ZZ-JC02221YXYJ009723YXYJ0142

2024

10.3969/j.issn.1006-4931.2024.10.009

中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子：1.369
ISSN：1006-4931
年,卷(期)：2024.33(10)
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