中国药业2024,Vol.33Issue(10) :48-55.DOI:10.3969/j.issn.1006-4931.2024.10.010

CRITIC-AHP复合赋权法结合Box-Behnken响应面法优选蜜桑叶炒制工艺

Optimization of Stir-Frying Process of Honey-Roasted Mori Folium Based on CRITIC-AHP Composite Weighting Method Combined with Box-Behnken Response Surface Methodology

陈泽键 徐晓青 韩燕全 朋汤义
中国药业2024,Vol.33Issue(10) :48-55.DOI:10.3969/j.issn.1006-4931.2024.10.010

CRITIC-AHP复合赋权法结合Box-Behnken响应面法优选蜜桑叶炒制工艺

Optimization of Stir-Frying Process of Honey-Roasted Mori Folium Based on CRITIC-AHP Composite Weighting Method Combined with Box-Behnken Response Surface Methodology

陈泽键 1徐晓青 2韩燕全 1朋汤义1
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作者信息

  • 1. 安徽中医药大学第一附属医院,安徽 合肥 230012;安徽中医药大学药学院,安徽 合肥 230031
  • 2. 安徽中医药大学第一附属医院,安徽 合肥 230012
  • 折叠

摘要

目的 优选蜜桑叶的炒制工艺.方法 以炒制温度、炒制时间、辅料用量为考察因素,以绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮、水分为指标成分,采用CRITIC熵权法及层次分析法(AHP)确定各指标成分的权重,以上述指标成分的综合评分为评价指标,采用Box-Behnken响应面法优选蜜桑叶炒制工艺并验证.结果 优选的炒制工艺为加 25%辅料,170℃炒制 10 min.绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮平均含量分别为 1.412,1.038,2.207,1.231,31.816,106.702 mg/g,水分平均含量为 10.99%.综合评分的理论值为 98.019 分,实测值(97.585 分)与之接近(RSD为 0.843%).结论 优选出的蜜桑叶炒制工艺稳定、合理、可行,可为蜜桑叶的工业化生产提供依据.

Abstract

Objective To optimize the stir-frying process of honey-roasted Mori Folium.Methods Chlorogenic acid,rutin,isoquercitrin,astragalin,ethanol-soluble extractives,total flavonoids and moisture were used as the indicator components.The CRITIC-entropy weight method and analytic hierarchy process(AHP)were used to determine the weights of each indicator component.The stir-frying process of honey-roasted Mori Folium was optimized by the Box-Behnken response surface methodology,with the stir-frying temperature,stir-frying time and excipient amount as the investigation factors,and with the comprehensive score of the above indicator components as the evaluation indicator.Then the verification test was conducted.Results The optimal stir-frying process was as follows:the excipient amount was 25%,the stir-frying temperature was 170℃,and the stir-frying time was 10 min.The average contents of chlorogenic acid,rutin,isoquercitrin,astragalin,ethanol-soluble extractives and total flavonoids were 1.412,1.038,2.207,1.231,31.816,106.702 mg/g respectively,and the average content of moisture was 10.99%.The theoretical value of the comprehensive score was 98.019 points,which was close to the measured value(97.585 points),with an RSD of 0.843%.Conclusion The optimal stir-frying process of honey-roasted Mori Folium is stable,rational and feasible,which can provide a basis for the industrial production of Mori Folium.

关键词

蜜桑叶/炒制工艺/Box-Behnken响应面法/CRITIC熵权法/层次分析法/超高效液相色谱法

Key words

honey-roasted Mori Folium/stir-frying process/Box-Behnken response surface methodology/CRITIC-entropy weight method/analytic hierarchy process/ultra-high-performance liquid chromatography

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基金项目

安徽省中医药学术流派传承工作室建设项目(第一批)(皖中医药发展秘[2021]30号)

出版年

2024
中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子:1.369
ISSN:1006-4931
参考文献量24
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