首页|CRITIC-AHP复合赋权法结合Box-Behnken响应面法优选蜜桑叶炒制工艺

CRITIC-AHP复合赋权法结合Box-Behnken响应面法优选蜜桑叶炒制工艺

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目的 优选蜜桑叶的炒制工艺。方法 以炒制温度、炒制时间、辅料用量为考察因素,以绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮、水分为指标成分,采用CRITIC熵权法及层次分析法(AHP)确定各指标成分的权重,以上述指标成分的综合评分为评价指标,采用Box-Behnken响应面法优选蜜桑叶炒制工艺并验证。结果 优选的炒制工艺为加 25%辅料,170℃炒制 10 min。绿原酸、芦丁、异槲皮苷、紫云英苷、醇溶性浸出物、总黄酮平均含量分别为 1。412,1。038,2。207,1。231,31。816,106。702 mg/g,水分平均含量为 10。99%。综合评分的理论值为 98。019 分,实测值(97。585 分)与之接近(RSD为 0。843%)。结论 优选出的蜜桑叶炒制工艺稳定、合理、可行,可为蜜桑叶的工业化生产提供依据。
Optimization of Stir-Frying Process of Honey-Roasted Mori Folium Based on CRITIC-AHP Composite Weighting Method Combined with Box-Behnken Response Surface Methodology
Objective To optimize the stir-frying process of honey-roasted Mori Folium.Methods Chlorogenic acid,rutin,isoquercitrin,astragalin,ethanol-soluble extractives,total flavonoids and moisture were used as the indicator components.The CRITIC-entropy weight method and analytic hierarchy process(AHP)were used to determine the weights of each indicator component.The stir-frying process of honey-roasted Mori Folium was optimized by the Box-Behnken response surface methodology,with the stir-frying temperature,stir-frying time and excipient amount as the investigation factors,and with the comprehensive score of the above indicator components as the evaluation indicator.Then the verification test was conducted.Results The optimal stir-frying process was as follows:the excipient amount was 25%,the stir-frying temperature was 170℃,and the stir-frying time was 10 min.The average contents of chlorogenic acid,rutin,isoquercitrin,astragalin,ethanol-soluble extractives and total flavonoids were 1.412,1.038,2.207,1.231,31.816,106.702 mg/g respectively,and the average content of moisture was 10.99%.The theoretical value of the comprehensive score was 98.019 points,which was close to the measured value(97.585 points),with an RSD of 0.843%.Conclusion The optimal stir-frying process of honey-roasted Mori Folium is stable,rational and feasible,which can provide a basis for the industrial production of Mori Folium.

honey-roasted Mori Foliumstir-frying processBox-Behnken response surface methodologyCRITIC-entropy weight methodanalytic hierarchy processultra-high-performance liquid chromatography

陈泽键、徐晓青、韩燕全、朋汤义

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安徽中医药大学第一附属医院,安徽 合肥 230012

安徽中医药大学药学院,安徽 合肥 230031

蜜桑叶 炒制工艺 Box-Behnken响应面法 CRITIC熵权法 层次分析法 超高效液相色谱法

安徽省中医药学术流派传承工作室建设项目(第一批)

皖中医药发展秘[2021]30号

2024

中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子:1.369
ISSN:1006-4931
年,卷(期):2024.33(10)
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