Objective To optimize the prescription of Gushang Dieda Kangfu Gel Plaster.Methods The prescription of the gel plaster was optimized by the Plackett-Burman test and the central composite design-response surface methodology(CCD-RSM),with the overall desirability(OD)value of initial viscosity,viscosity retention and comprehensive sensory score of the gel plaster as the evaluation indicator,and with the dosages of sodium polyacrylate,aluminium glycinate,povidone K90,tartaric acid,glycerol and traditional Chinese medicine powder as the influencing factors.Then the verification test was conducted.Results The key factor in the preparation process of the gel plaster was the dosages of sodium polyacrylate,aluminum glycinate and povidone K90.The optimal formula was as follows:sodium polyacrylate was 5.5 g,povidone K90 was 2.9 g,and aluminum glycinate was 0.2 g.The average OD value of the three batches of gel plaster was 0.804 4,which was close to the theoretical value(0.817),with an RSD of 1.90%.Conclusion The Gushang Dieda Kangfu Gel Plaster prepared by the optimal prescription has uniform appearance and good viscosity,which meet the quality requirements of gel plaster.
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