Optimization of the Preparation for the Test Solution of Huangqi Compound Preparation
Objective To optimize the preparation method of the test solution of Huangqi Compound Preparation.Methods The preparation method of the test solution was optimized with the extraction solvent as the influencing factor and the content of astragaloside Ⅳ in the Fuzheng Qiangjin Tablets as the investigation indicator.The above optimal method was verified with four commercial Huangqi Compound Preparations(Qianlietong Tablets,Compound Shiwei Tablets,Qiming Granules,Compound Xueshuantong Capsules)as the test subjects.Results The optimal method was that the ammonia test solution-water-water saturated n-butanol(10∶30∶50,V/V/V)was used for heating reflux extraction based on the method of Chinese Pharmacopoeia;the content of astragaloside Ⅳ determined by the above method was 1.09 mg/g with an RSD of 1.93%.The content of astragaloside Ⅳ in four compound preparations determined by the above optimal method was in the range of 1.8 to 2.6 times higher than that determined by the method of Chinese Pharmacopoeia,with an RSD in the range of 1.61%to 4.73%.Conclusion This method is fast,efficient,specific,repeatable,accurate and has low systematical error,which can be used for the preparation of the test solution of Huangqi Compound Preparation.
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