Objective To investigate the clinical efficacy of Huhuang Burn Liniment combined with conventional therapy in the treatment of diabetic foot of Wagner grades 1-2.Methods A total of 94 patients with diabetic foot of Wagner grades 1-2 admitted to the Dazu Hospital of Chongqing Medical University from January 2022 to June 2023 were selected and divided into the control group and the observation group by the random number table method,with 47 cases in each group.The patients in the two groups were treated with conventional hypoglycemic drugs,and the necrotic tissue was cleared by the silkworm-feeding debridement method,on this basis,the patients in the observation group were treated with Huhuang Burn Liniment.Both groups were treated continuously for 28 d.Results The efficacy in the observation group was better than that in the control group(P<0.05).The infection rate of diabetic foot in the observation group was 2.13%,which was significantly lower than 14.89%in the control group(P<0.05).Compared with those in the control group,the wound surface area in the observation group significantly decreased,the wound surface healing time significantly shortened,the vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),tissue inhibitor of metalloproteinases-1(TIMP-1)and transforming growth factor-β(TGF-β)levels significantly increased,the matrix metalloproteinase-9(MMP-9)level significantly decreased on the 7th,14th and 28th days of treatment(P<0.05).Conclusion Huhuang Burn Liniment combined with conventional therapy in the treatment of diabetic foot of Wagner grades 1-2 can increase the VEGF,EGF,TIMP-1,TGF-β levels,decrease the MMP-9 level,and promote the wound surface healing.
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