Clinical Observation of Carbon Dioxide Laser Combined with Clotrimazole Vaginal Tablets in the Treatment of Recurrent Vulvovaginal Candidiasis
Objective To investigate the clinical efficacy of carbon dioxide(CO2)laser combined with Clotrimazole Vaginal Tablets in the treatment of recurrent vulvovaginal candidiasis(RVVC).Methods A total of 100 patients with RVVC admitted to the hospital from July 2021 to June 2022 were selected and randomly divided into the control group and the observation group,with 50 cases in each group.The patients in the two groups were treated with Clotrimazole Vaginal Tablets,on this basis,the patients in the observation group were treated with CO2 laser.Both groups were treated continuously for six months and followed up at one,three,six and twelve months after treatment.Results The total effective rate in the observation group was 92.00%,which was significantly higher than 72.00%in the control group(P<0.05).After treatment,the cases of vaginal microbiota density and vaginal microbiota diversity of grades Ⅱ-Ⅲ in the observation group were more than those in the control group;and the normal rate of vaginal microenvironment in the observation group was 86.00%,which was significantly higher than 46.00%in the control group(P<0.05).After treatment,the interleukin-6(IL-6),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)levels in the observation group were significantly lower than those in the control group(P<0.05),the disappearance time of abnormal leucorrhea,vulva itching,vulva burning pain,redness and swelling of mucosa was significantly shorter than that in the control group(P<0.05).The recurrence rates at three,six,and twelve months after treatment in the observation group were significantly lower than those in the control group(P<0.05).Conclusion CO2 laser combined with Clotrimazole Vaginal Tablets can effectively improve clinical symptoms,restore vaginal microbiota balance,relieve inflammatory reactions,shorten symptom disappearance time,and decrease recurrence in patients with RVVC.
CO2 laserClotrimazole Vaginal Tabletsrecurrent vulvovaginal candidiasisvaginal microbiotainflammatory factorclinical efficacy
万方数据
维普
