Objective To investigate the influencing factors of bleeding induced by rivaroxaban in Asian patients.Methods The studies related to the influencing factors of bleeding induced by rivaroxaban in Asian patients in the PubMed,Medline,The Cochrane Library,CNKI,VIP,WanFang and CBM from the inception of each database to December 31,2022 were searched.The RevMan 5.4 statistical software was used for Meta-analysis.Results A total of 12 studies were included,involving 18 211 patients.Male[OR=2.02,95%CI(1.59,2.57),P<0.01],history of bleeding[OR=3.41,95%CI(1.84,6.35),P<0.01],creatinine clearance rate(CCr)<50 mL/min[OR=2.29,95%CI(1.77,2.95),P<0.01],use of dual antiplatelet drugs[aspirin+clopidogrel;OR=2.15,95%CI(1.69,2.74),P<0.01],use of nonsteroidal anti-inflammatory drugs[OR=3.06,95%CI(1.87,45.00),P<0.01],CHA2DS2-VASc score>four points[OR=1.65,95%CI(1.29,2.13),P<0.01],prothrombin time(PT)>13 s[OR=3.01,95%CI(1.82,4.99),P<0.01],and daily dose of rivaroxaban≥20 mg[OR=2.59,95%CI(1.82,3.70),P<0.01]were the risk factors of bleeding induced by rivaroxaban in Asian patients(P<0.01).Conclusion Clinical medical staff should pay attention to the male patients with a history of bleeding,PT>13 s,CCr<50 mL/min,use of dual antiplatelet drugs,and CHA2DS2-VASc score>four points,give drugs at a small dose(<20 mg)as much as possible,and be alert to the occurrence of haemorrhages.
关键词
利伐沙班/亚洲患者/出血/药品不良反应/危险因素/Meta分析
Key words
rivaroxaban/Asian patient/bleeding/adverse drug reaction/risk factor/Meta-analysis
维普
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