Elemene in the Treatment of Elderly Refractory/Recurrent Acute Myeloid Leukemia:A Case Report and Literature Analysis
Objective To provide a reference for further research of elemene in the treatment of leukemia.Methods The treatment process of an elderly(65 years)patient with refractory/recurrent acute myeloid leukemia(AML)who achieved complete bone marrow remission after receiving elemene when the disease recurred was retrospectively analyzed,the effectiveness of the regimen and the possible mechanism of elemene were analyzed and explored based on the literature.Results After diagnosis,the patient had received multiple chemotherapy regimens with a certain efficacy,but she experienced multiple adverse reactions such as bone marrow suppression of grade Ⅳ and recurrent disease.After treatment with elemene,the patient's primitive cells disappeared,minimal residual disease remained negative,and her quality of life significantly improved.Previous studies showed that elemene could inhibit the growth of leukemia cells through mechanisms such as direct cytotoxic effects,promotion of tumor cell apoptosis and reversal of multi-drug resistance.Conclusion Elemene may treat leukemia by regulating multiple key signaling pathways,but the specific mechanism and related targets are not yet clear.
elemeneelderlyrefractory acute myeloid leukemiarecurrent acute myeloid leukemiacase analysisliterature analysispharmaceutical care
万方数据
维普
