Objective To provide a reference for further research of elemene in the treatment of leukemia.Methods The treatment process of an elderly(65 years)patient with refractory/recurrent acute myeloid leukemia(AML)who achieved complete bone marrow remission after receiving elemene when the disease recurred was retrospectively analyzed,the effectiveness of the regimen and the possible mechanism of elemene were analyzed and explored based on the literature.Results After diagnosis,the patient had received multiple chemotherapy regimens with a certain efficacy,but she experienced multiple adverse reactions such as bone marrow suppression of grade Ⅳ and recurrent disease.After treatment with elemene,the patient's primitive cells disappeared,minimal residual disease remained negative,and her quality of life significantly improved.Previous studies showed that elemene could inhibit the growth of leukemia cells through mechanisms such as direct cytotoxic effects,promotion of tumor cell apoptosis and reversal of multi-drug resistance.Conclusion Elemene may treat leukemia by regulating multiple key signaling pathways,but the specific mechanism and related targets are not yet clear.
关键词
榄香烯/老年/难治性急性髓系白血病/复发性急性髓系白血病/病例分析/文献分析/药学监护
Key words
elemene/elderly/refractory acute myeloid leukemia/recurrent acute myeloid leukemia/case analysis/literature analysis/pharmaceutical care
维普
万方数据