Bibliometric Analysis of Physiologically-Based Pharmacokinetic Model Research
Objective To understand the current status,knowledge base,and academic influence of physiologically-based pharmacokinetic(PBPK)model research,and to provide a reference for future research and application of PBPK models.Methods The literature related to PBPK model researches from January 1,1999 to April 1,2023 in the Web of Science database was searched,and Excel 2019 software,Incites analysis platform,VOSviewer 1.6.19 software were adopted to conduct bibliometric analysis to qualitatively and quantitatively analyze the number of publications,countries/regions,institutions,authors,journals,citations and keywords.Results A total of 2 923 articles were included,of which 244 articles were published by Chinese scholars.The number of annual publications in this field has been increasing year by year,and the country with the largest number of publications was the United States of America(USA,48.82%),followed by the United Kingdom(20.80%)and Germany(10.50%),the category normalized citation impacts(CNCIs)of the USA,the United Kingdom,and Germany were 1.26,1.55,and 1.41,respectively.The number of publications in mainland China ranked the fifth(7.90%),with a CNCI of 0.84.The institution with the largest number of publications in the whole world was the Roche Holding(198 articles),with a CNCI of 1.74,while the institution with the largest number of publications in China was the China Pharmaceutical University(40 articles),with a CNCI of 0.93.The top 10 authors in terms of publication number all came from the top 10 countries in terms of publication number,with CNCIs of>1.The journal with the largest number of publications was Drug Metabolism and Disposition(206 articles).The research topics focused on the application of PBPK model to study drug absorption,distribution,metabolism,elimination and drug-drug interactions,and the research hotspots included the application of PBPK model in special populations,drug-drug interactions,and monoclonal antibody drugs.Conclusion PBPK model research has developed rapidly in the field of pharmacy from 1999 to 2023.Institutions,journals,and scholars from the USA,and the United Kingdom have led the development of international PBPK model research.The PBPK model research in China follows the international development trend,but the academic influence needs to be further improved.
国家科技期刊平台
NSTL
万方数据
