Distribution and Drug Resistance of Lower Respiratory Pathogenic Bacteria in a Hospital from 2019 to 2021
Objective To analyze the distribution and drug resistance of pathogenic bacteria in inpatients with lower respiratory tract infection in a hospital,and to promote the rational use of antibiotics in the clinic.Methods A total of 12 040 inpatients with lower respiratory tract infection admitted to the Beijing Pinggu District Hospital from January 2019 to December 2021 were selected for statistical analysis of bacterial culture and drug susceptibility test results of the lower respiratory tract isolated samples,and the rationality of antibiotics prescriptions was evaluated according to the guidelines.Results A total of 5 074 qualified lower respiratory tract specimens were sent for testing,with a pathogen detection rate of 42.14%(5 074/12 040).A total of 3 137 strains of pathogenic bacteria were isolated,including 2 966 strains of gram-negative bacteria(94.55%)and 171 strains of gram-positive cocci(5.45%).The common gram-negative bacteria included 889 strains of Klebsiella pneumoniae(28.34%),819 strains of Pseudomonas aeruginosa(26.11%),284 strains of Acinetobacter baumannii(9.05%),212 strains of Stenotrophomonas maltophilia(6.76%),168 strains of Enterobacter cloacae(5.36%),and 163 strains of Escherichia coli(5.20%).The resistance rates of Klebsiella pneumoniae,Pseudomonas aeruginosa,and Acinetobacter baumannii to imipenem were 5.85%,16.12%,and 13.03%,respectively.Staphylococcus aureus(111 strains,3.54%)was the main gram-positive coccus,with a resistance rate of 0 to vancomycin and linezolid,and a resistance rate of 90.99%to penicillin.A total of 4 719 irrational antibiotics prescriptions were collected,with irrational drug use rates of 41.43%,35.16%,and 33.95%for ciprofloxacin,levofloxacin,and cotrimoxazole,respectively.The common irrational drug use behaviors included improper selection of drug varieties(40.16%),irrational combination of drug use(15.60%),and use without indication(13.67%).Conclusion Gram-negative bacteria are the main pathogen of lower respiratory tract infection in the hospital.Common pathogens have different degrees of resistance to antibiotics.Strengthening the monitoring and analysis of their resistance can promote the rational selection of antibiotics.
Department of Respiratorylower respiratory tract infectionpathogensdrug resistancerational drug use
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