Rationality Analysis of Anticoagulant Drug Use Among Patients Undergoing Orthopedic Surgery in a Hospital
Objective To promote the rational use of anticoagulant drugs in clinical practice.Methods The medical records of patients underwent orthopedic surgery in the Suining Central Hospital from January to June 2022 were extracted retrospectively from the hospital information system,the information on the patients′ gender,age,body mass,surgical type and anticoagulant drug use was collected.Based on the drug instructions,the evaluation criteria for the rationality of anticoagulant drug use in hospital were formulated according to the relevant guidelines and expert consensuses to evaluate the rationality of anticoagulant drug use in patients.Results A total of 411 patients were collected,including 393 cases(609 case times)of irrational drug use.The top three types of irrational drug use in terms of incidence were inappropriate medication timing(255 case times,41.87%),inappropriate indications(114 case times,18.72%),inappropriate usage and dosage(113 case times,18.56%).The inappropriate medication timing was mainly induced by early initiation of anticoagulation after surgery(245 case times),including 233 case times of using enoxaparin sodium(95.10%),11 case times of using apixaban(4.49%),one case time of using fondaparinux sodium(0.41%).The inappropriate indication was mainly induced by off-label drug use(106 case times,92.98%).Inappropriate usage and dosage were mainly induced by high preventive doses(56 case times,49.56%)and low treatment dose(51 case times,45.13%).Conclusion The irrational use of anticoagulant drugs among patients undergoing orthopedic surgery in this hospital is serious.It is necessary to strengthen the professional knowledge training for clinical physicians and pharmacists on anticoagulation-related guidelines and drug instructions to improve clinical awareness of rational drug use,and ensure the medication safety of patients.
anticoagulant drugorthopedic surgeryperioperative periodinpatientrational drug usemedication evaluation
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