Clinical Pharmacist' Clinical Practice in a Case of Vancomycin-Induced Drug-Induced Liver Injury and Drug Fever
Objective To promote the rational use of vancomycin in the clinic.Methods A clinical pharmacist participated in the treatment process of a case of drug-induced liver injury(DILI)and drug fever caused by vancomycin,and provided pharmaceutical care for the patient.Based on literature and changes in the patient's daily examination indicators,the clues leading to DILI and drug fever were discovered on time,and the drugs were stopped and treated accordingly.Results The drugs causing DILI was identified through the RUCAM score,and the drugs causing drug fever was found through exclusion diagnosis.Literature review and patient's examination indicators were used to infer that the vancomycin-induced DILI and drug fever occurred simultaneously,which was related to hypersensitivity reactions in humoral immunity.Conclusion When using vancomycin in the clinic,in addition to paying attention to adverse reactions of renal function in patients,attention should also be paid to changes in liver function and body temperature.If liver function injury or high body temperature occurs,it is necessary to be alert to adverse drug reactions induced by vancomycin.
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