Efficacy of Modified Chaihu Shugan Powder Granules Combined with Acupoint Application in the Treatment of Insomnia and Its Effects on TLR/NF-κB Signaling Pathway
Objective To investigate the efficacy of modified Chaihu Shugan Powder Granules combined with acupoint application in the treatment of insomnia,and its effects on the Toll-like receptor(TLR)/nuclear factor-κB(NF-κB)signaling pathway.Methods A total of 100 insomnia patients admitted to the hospital from January 2021 to January 2023 were selected and divided into the observation group and the control group by the random number table method,with 50 cases in each group.The patients in the two groups were given oral Dexzopiclone Tablets before bedtime,on this basis,the patients in the observation group were given modified Chaihu Shugan Powder Granules combined with Ningjing Patch applied to Neiguan and Shenmen acupoints.Both groups were treated continuously for two weeks.Results The total effective rate in the observation group was 96.00%,which was significantly higher than 84.00% in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome(difficulty falling asleep,frequent dreaming and easy awakening,fatigue and lack of appetite,red eyes and bitter mouth,red tongue and lack of saliva,wiry and rapid pulse)scores in the two groups significantly decreased,the Self-Rating Scale of Sleep(SRSS)and Pittsburgh Sleep Quality Index(PSQI)scores significantly decreased,the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)scores significantly decreased,the expression levels of TLR3,TLR4,myeloid differentiation factor(MyD88),TAK1-binding protein 2(TAB2)and NF-κB mRNA significantly decreased;the total sleep time,rapid eye movement sleep,sleep latency,wake-up time and sleep efficiency all significantly improved(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(20.00% vs.14.00%,P>0.05).Conclusion Modified Chaihu Shugan Powder Granules combined with acupoint application can effectively improve the clinical symptoms,sleep quality and sleep structure of patients with insomnia,it can also improve the patients' anxiety and depression emotions,and regulate the TLR/NF-κB signaling pathway.
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