Clinical Observation of Bailing Capsules Combined with Dapagliflozin in the Treatment of Early Diabetic Nephropathy
Objective To investigate the clinical efficacy of Bailing Capsules combined with dapagliflozin in the treatment of early diabetic nephropathy(DN).Methods A total of 103 patients with early DN admitted to the hospital from February 2020 to February 2023 were selected and divided into the control group(46 cases)and the observation group(57 cases)based on different treatment regimens.The patients in the two groups were given conventional treatment and oral Dapagliflozin Tablets to control blood glucose,on this basis,the patients in the observation group were given Bailing Capsules.Both groups were treated continuously for 12 weeks.Results The total effective rate in the observation group was 89.47%,which was significantly higher than 71.74% in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores in the two groups significantly decreased;the fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1C)and malondialdehyde(MDA)levels significantly decreased;the superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels significantly increased;the blood urea nitrogen(BUN)and serum creatinine(SCr)levels,and urine albumin/creatinine ratio(UACR)significantly decreased,and estimated glomerular filtration rate(eGFR)significantly increased;the hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels significantly decreased(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(3.51% vs.2.17%,P>0.05).Conclusion Bailing Capsules combined with dapagliflozin can improve blood glucose levels,oxidative stress state,renal function and clinical symptoms,and relieve the inflammatory reactions in patients with early DN.
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