Research on the Theoretical Basis of Coptidis Rhizoma in the Treatment of Hyperlipidemia Based on the Theory of "Heart Connecting with Small Intestine"
Objective To investigate the theoretical basis of Coptidis Rhizoma in the treatment of hyperlipidemia.Methods By sorting out the relationship of the theory of "heart connecting with small intestine" with the etiology and pathogenesis of hyperlipidemia,the theoretical basis of Coptidis Rhizoma in the treatment of hyperlipidemia was explored based on the effects of Coptidis Rhizoma on the gastrointestinal microecosystem.Results The main etiology and pathogenesis of hyperlipidemia in traditional Chinese medicine are improper diet,long-time sitting and lack of exercise,resulting in spleen dysfunction,liver dysfunction,phlegm fluid induced by internal stagnation of fluid-dampness,phlegm stagnation,intermingled phlegm and blood stasis,and transformation into lipid paste.The dysfunction of heart connecting with small intestine can cause the abnormal circulation of clear and turbid Qi in the body,thus the clear Qi cannot rise up,resulting in the swill diarrhea,while the turbid Qi cannot descend,resulting in the pathological substances such as phlegm fluid,water dampness,and turbid toxins that cannot be removed,and the turbid lipid paste will be generated over time.Coptidis Rhizoma can clear the heart and dry the dampness,rise the clear Qi and descend the turbid Qi,which is a classic medicine in the treatment of hyperlipidemia based on the theory of"heart connecting with small intestine".Berberine has a significant lipid-lowering effect,and it can improve the lipid metabolism without obvious side effects,and the intestinal microbiota is an important mediator for the lipid-lowering effect of berberine.Conclusion Based on the theory of "heart connecting with small intestine",paying attention to the physiological and pathological characteristics of the small intestine and the metabolic characteristics of the intestinal microbiota may be the important directions for further exploring the specific mechanism of Coptidis Rhizoma in the treatment of hyperlipidemia.
hyperlipidemiathe theory of "heart connecting with small intestine"Coptidis Rhizomaberberineintestinal microbiota
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