Objective To optimize the preparation process for Feiyan Mixture.Methods With comprehensive score of ephedrine hydrochloride content and extract rate as the evaluation index,the L9(34)orthogonal test was used to optimize the extraction process of Feiyan Mixture with water addition,decoction time,and decoction times as the investigation factors.Single factor test was used to investigate the concentration temperature and purification process,and validation test was carried out.Results The optimal extraction process was as follows:decocting twice,adding eight times the amount of water for the first time and six times the amount of water for the second time,decocting for 1.5 h each time,controlling the concentration temperature in the range of 55-85℃under reduced pressure(pressure of 0.05 mbar),and filtering by a centrifuge(speed of 10 000 r/min,centrifuge radius of 92 mm).The ephedrine content in three samples prepared by the optimal process was 0.14 mg/mL,and the extract rate was 10.66%.Conclusion The optimal extraction process is scientific,reasonable,easy to operate,and has good stability and repeatability,which can provide experimental evidence for the industrial production of Feiyan Mixture.
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