首页|L9(34)正交试验法优选肺炎合剂制备工艺

L9(34)正交试验法优选肺炎合剂制备工艺

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目的 优选肺炎合剂的制备工艺。方法 以盐酸麻黄碱含量及干膏率的综合评分为评价指标，以加水量、煎煮时间、煎煮次数为考察因素，采用L9(34)正交试验法优选肺炎合剂水提取工艺，采用单因素试验法考察其浓缩温度及纯化工艺，并进行验证试验。结果 优选最佳制备工艺为煎煮 2 次，第 1 次加 8 倍量水，第 2 次加 6 倍量水，每次煎煮 1。5h，煎液减压(压强为 0。05 mbar)浓缩温度控制在55～85℃，采用离心机(转速为 10 000 r/min，离心半径为 92 mm)过滤。按优选工艺制备的3份样品中，盐酸麻黄碱含量为0。14 mg/mL，干膏率为 10。66%。结论 优选工艺科学、合理，操作简便，且稳定性、重复性好，可为肺炎合剂的工业化生产提供试验依据。
Optimization of Preparation Process for Feiyan Mixture by the L9(34)Orthogonal Test
Objective To optimize the preparation process for Feiyan Mixture.Methods With comprehensive score of ephedrine hydrochloride content and extract rate as the evaluation index,the L9(34)orthogonal test was used to optimize the extraction process of Feiyan Mixture with water addition,decoction time,and decoction times as the investigation factors.Single factor test was used to investigate the concentration temperature and purification process,and validation test was carried out.Results The optimal extraction process was as follows:decocting twice,adding eight times the amount of water for the first time and six times the amount of water for the second time,decocting for 1.5 h each time,controlling the concentration temperature in the range of 55-85℃under reduced pressure(pressure of 0.05 mbar),and filtering by a centrifuge(speed of 10 000 r/min,centrifuge radius of 92 mm).The ephedrine content in three samples prepared by the optimal process was 0.14 mg/mL,and the extract rate was 10.66%.Conclusion The optimal extraction process is scientific,reasonable,easy to operate,and has good stability and repeatability,which can provide experimental evidence for the industrial production of Feiyan Mixture.

Feiyan MixtureL9(34)orthogonal testephedrine hydrochlorideextract rateprocess optimization

胡彦君、黄洁瑶、肖亚平、钟良才、方伟、李柏群

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重庆大学附属三峡医院,重庆 404000

肺炎合剂 L9(34)正交试验法 盐酸麻黄碱 干膏率 工艺优选

中国博士后科学基金71批面上资助地区专项支持计划重庆市自然科学基金面上项目重庆市卫生健康委员会中医药科研项目重庆市万州区科技计划项目重庆市万州区科卫联合医学科研项目重庆市万州区科卫联合医学科研项目重庆大学附属三峡医院院级科研项目

2022MD713718cstc2020jcyjmsxmX10712024ZYQN013wzstc-2020023wzstckw2020038wzstckw20230172022YJKYXM-005

2024

10.3969/j.issn.1006-4931.2024.15.010

中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子：1.369
ISSN：1006-4931
年,卷(期)：2024.33(15)