中国药业2024,Vol.33Issue(15) :84-87.DOI:10.3969/j.issn.1006-4931.2024.15.021

养元健骨汤联合常规补钙对老年股骨粗隆间骨折髓内钉术后患者骨密度及骨折愈合速度的影响

Effect of Yangyuan Jiangu Decoction Combined with Routine Calcium Supplementation on Bone Mineral Density and Fracture Healing Speed in Elderly Patients with Intertrochanteric Fracture After Intramedullary Nail Surgery

朱发军 张屹 胡东 陈辉 王晶 臧红春 吴新淼 王维星 张永光 侍氢
中国药业2024,Vol.33Issue(15) :84-87.DOI:10.3969/j.issn.1006-4931.2024.15.021

养元健骨汤联合常规补钙对老年股骨粗隆间骨折髓内钉术后患者骨密度及骨折愈合速度的影响

Effect of Yangyuan Jiangu Decoction Combined with Routine Calcium Supplementation on Bone Mineral Density and Fracture Healing Speed in Elderly Patients with Intertrochanteric Fracture After Intramedullary Nail Surgery

朱发军 1张屹 1胡东 1陈辉 1王晶 1臧红春 1吴新淼 1王维星 1张永光 1侍氢1
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作者信息

  • 1. 江苏省宿迁市中西医结合医院,江苏 宿迁 223800
  • 折叠

摘要

目的 探讨养元健骨汤联合常规补钙对老年股骨粗隆间骨折髓内钉术后患者骨密度及骨折愈合速度的影响.方法 选取医院2018 年 1 月至 2022 年 2 月收治的老年股骨粗隆间骨折行髓内钉术的患者 90 例,按随机数字表法分为常规补钙组和养元健骨汤组,各 45 例.两组患者术后均予常规补钙治疗,养元健骨汤组患者加用养元健骨汤,均持续治疗 1 个月.结果 养元健骨汤组总有效率为93.33%,显著高于常规补钙组的 73.33%(P<0.05).治疗后,两组患者的骨代谢指标β胶联降解产物含量均显著减少(P<0.05),Ⅰ型胶原氨基端肽原、血清骨钙素含量均显著增加(P<0.05),且养元健骨汤组均显著优于常规补钙组(P<0.05);两组患者的Harris髋关节功能评分量表(HHS)评分、骨密度均显著升高(P<0.05),且养元健骨汤组均显著高于常规补钙组(P<0.05);养元健骨汤组患者的股骨骨折愈合时间显著短于常规补钙组(P<0.05).养元健骨汤组和常规补钙组不良反应发生率相当(6.67%比4.44%,P>0.05).结论 养元健骨汤联合常规补钙治疗老年股骨粗隆间骨折髓内钉术后的临床疗效良好,能增加患者的骨密度,加快骨折愈合速度,且安全性良好.

Abstract

Objective To investigate the effect of Yangyuan Jiangu Decoction combined with routine calcium supplementation on bone mineral density and fracture healing speed in elderly patients with intertrochanteric fracture after intramedullary nail surgery.Methods A total of 90 elderly patients who underwent intramedullary nail surgery for intertrochanteric fracture of the femur admitted to the hospital from January 2018 to February 2022 were selected and divided into the routine calcium supplementation group and the Yangyuan Jiangu Decoction group by the random number table method,with 45 cases in each group.The patients in the two groups were treated with routine calcium supplementation after surgery,while the patients in the Yangyuan Jiangu Decoction group received additional treatment with Yangyuan Jianggu Decoction.Both groups were treated for one month.Results The total effective rate in the Yangyuan Jiangu Decoction group was 93.33%,which was significantly higher than 73.33%in the routine calcium supplementation group(P<0.05).After treatment,the content of bone metabolism indexes such as β-collagen degradation products(β-CTX)in the two groups significantly decreased(P<0.05),while the levels of procollagen typeⅠamino terminal peptide(PⅠNP)and serum osteocalcin(OC)in the two groups significantly increased(P<0.05),and those in the Yangyuan Jiangu Decoction group were significantly better than those in the routine calcium supplementation group(P<0.05).The Harris Hip Scale(HHS)score and bone mineral density(BMD)in the two groups significantly increased(P<0.05),and those in the Yangyuan Jiangu Decoction group were significantly higher than those in the routine calcium supplementation group(P<0.05).The femoral fracture healing time in the Yangyuan Jiangu Decoction group was significantly shorter than that in the routine calcium supplementation group(P<0.05).The incidence of adverse reactions was comparable between the Yangyuan Jiangu Decoction group and the routine calcium supplementation group(6.67%vs.4.44%,P>0.05).Conclusion Yangyuan Jiangu Decoction combined with routine calcium supplementation has good efficacy and safety in the treatment of elderly patients with intertrochanteric fractures after intramedullary nail surgery,which can increase the patient's BMD and fracture healing speed.

关键词

养元健骨汤/常规补钙/股骨骨折/髓内钉术/骨密度/骨折愈合速度

Key words

Yangyuan Jiangu Decoction/routine calcium supplementation/femoral fracture/intramedullary nail surgery/bone mineral density/fracture healing speed

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基金项目

2019年度江苏省中医药科技发展计划项目(Z2019080)

出版年

2024
中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子:1.369
ISSN:1006-4931
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