Comparison of the Effects of Micro-Stimulation Scheme and Antagonist Scheme on Ovulation Induction Outcomes and Clinical Pregnancy Outcomes in Patients with Poor Ovarian Response
Objective To compare the effects of micro-stimulation and antagonist on ovulation induction outcomes and clinical pregnancy outcomes in patients with poor ovarian response(POR).Methods A total of 371 patients with POR who received micro-stimulation and antagonist in the hospital from March 2016 to January 2022 were selected and divided into micro-stimulation group(185 cases)and antagonist group(186 cases)according to different treatment regimens during the ovulation cycle.The ovulation induction outcomes[amount of gonadotropins(Gn),Gn use time,total number of harvest eggs,number of 2PN,number of transplantable embryos,and number of high-quality embryos]and clinical pregnancy outcomes(cycle cancellation rate,clinical pregnancy rate,biochemical pregnancy rate,twin rate,abortion rate,and live birth rate)during in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy were compared between the two groups.Results The anti-mullerian hormone(AMH),the amount of Gn and Gn use time,total number of harvest eggs,number of 2PN,and number of transplantable embryos in the micro-stimulation group were significantly lower than those in the antagonist group(P<0.01).The cycle cancellation rate in the micro-stimulation group was 83.24%,which was significantly higher than 66.67%in the antagonist group(P<0.01).The clinical pregnancy rate in the mioro-stimulation group was lower than that in the antagonist group,without significant difference(48.39%vs.40.32%,P>0.05).Conclusion Micro-stimulation can reduce the dosage and duration of Gn in patients with POR,with a slightly higher clinical pregnancy rate,which may be a more feasible plan.However,the cancellation rate of the cycle is high,and the selection needs to be based on the patient's ovarian function.
micro-stimulation schemeantagonist schemepoor ovarian responsein vitro fertilizationembryo transfer
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