Effect of Clopidogrel Combined with Telgrello on the OTC Indexes in Patients with ST-Segment Elevation Myocardial Infarction
Objective To investigate the effect of clopidogrel combined with ticagrelor on the stability of atherosclerotic plaque in patients with acute ST-segment elevation myocardial infarction(STEMI)based on optical coherence tomography(OCT).Methods A total of 105 patients with acute STEMI admitted to the Binhai County People's Hospital from January 2020 to January 2023 were retrospectively selected and divided into the conventional group(52 cases)and the combined group(53 cases)according to different treatment regimens.The patients in the two groups were treated with clopidogrel,on this basis,the patients in the combined group were treated with ticagrelor.Both groups were treated for 12 months.Results The total effective rate in the combined group was 84.91%,which was significantly higher than 65.38%in the conventional group(P<0.05).After treatment,the minimum fiber cap thickness in the combined group was significantly greater than that in the conventional group(P<0.05),while the lipid radian in the combined group was significantly smaller than that in the conventional group(P<0.05),and the improvement in the combined group was significantly greater than that in the conventional group(P<0.05).There was no significant difference in the minimum luminal area between the two groups(P>0.05),but the increase in minimum luminal area in the combined group was significantly higher than that in the conventional group(P<0.05).The whole blood viscosity,plasma viscosity,and hematocrit in the two groups significantly decreased(P<0.05),and those in the combined group were significantly lower than those in the conventional group(P<0.05).The incidence of adverse reactions in the combination group was 5.66%,which was significantly lower than 19.23%in the conventional group(P<0.05).Conclusion Clopidogrel combined with ticagrelor has good clinical efficacy and safety in the treatment of acute STEMI,which can improve the stability of atherosclerotic plaque,and promote the recovery of vascular function.
万方数据
维普
