Clinical Observation of Litan Decoction Combined with Budesonide Formoterol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm-Turbidity Obstructing Lung Syndrome
Objective To investigate the clinical efficacy of Litan Decoction combined with budesonide formoterol in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm-turbidity obstructing lung syndrome,and its effect on lung function and immune function.Methods A total of 116 patients with AECOPD with phlegm-turbidity obstructing lung syndrome admitted to the hospital from June 2019 to December 2022 were selected and randomly divided into the control group and the observation group,with 58 cases in each group.The patients in the two groups were treated with budesonide formoterol atomization inhalation,on this basis,the patients in the observation group were treated with Litan Decoction.Both groups were treated for three months.Results The total effective rate in the observation group was 93.10%,which was significantly higher than 77.59%in the control group(P<0.05).After treatment,the lung function indexes[forced expiratory volume in one second(FVE1),forced vital capacity(FVC),FVE1/FVC]in the two groups significantly increased(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The T lymphocyte subsets CD4+and CD4+/CD8+in the two groups significantly increased(P<0.05),while the T lymphocyte subsets CD8+in the two groups significantly decreased(P<0.05),and the improvement of the above indexes in the observation group was significantly better than that in the control group(P<0.05).The TCM syndrome scores in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).Two and three months after treatment,the COPD Assessment Test(CAT)scores in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(13.79%vs.24.14%,P>0.05).Conclusion Litan Decoction combined with budesonide formoterol has clinical efficacy and safety in the treatment of patients with AECOPD with phlegm-turbidity obstructing lung syndrome,which can improve the patients'lung function,immune function,and traditional Chinese medicine syndrome.
Litan Decoctionbudesonide formoterolacute exacerbation of chronic obstructive pulmonary diseasephlegm-turbidity obstructing lung syndromelung functionimmune function
万方数据
维普
