Effect Evaluation of Clinical Pharmacists' Participation in the Management of Antibiotic Use in the Intensive Care Unit of a Grade-A Tertiary Hospital
Objective To promote the rational use of antibiotics in clinical departments of hospitals.Methods The data on the antibiotic use in the Intensive Care Unit of a hospital from January to June 2022(before intervention)and July to December 2022(after intervention)were collected by the PASS clinical pharmacy management system and rational drug use monitoring system.A PDCA cycle for antibiotic use management participated by clinical pharmacists was established,with a target value of antibiotics use density(AUD)decreasing to 95 DDDs/100 person-days.A total of 400 medical records before and after intervention(200 for each time period)in the department were extracted to evaluate the rationality of antibiotic use.Results After intervention,the AUD of the department decreased from(107.64±8.79)DDDs/100 person-days to(83.25±10.15)DDDs/100 person-days(P<0.01),the antibiotic use rate and consumption sum per capita decreased by 9.31%and CNY 938.29,respectively.After intervention,the use rates of antibiotics for non-restricted use,restricted use and special use decreased by 0.39%,5.32%,and 3.60%,respectively.After intervention,the use rate of antibiotics in discharged patients decreased by 9.31%,while the proportion of patients with single use of antibiotics increased by 9.66%.After intervention,the irrational use rate of antibiotics in case samples decreased by 13.00%,the main types of irrational use before intervention were inappropriate usage and dosage,medication without indication,and inappropriate treatment course,those after intervention were inappropriate usage and dosage and inappropriate treatment course.Conclusion Clinical pharmacists participating in the PDCA cycle for antibiotic use management can effectively control the AUD and improve the rationality of antibiotic use.
antibiotics use densityIntensive Care Unitclinical pharmacistPDCA cyclerational drug use
国家科技期刊平台
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