AHP-CRITIC法结合正交试验法优选如意凝胶贴膏提取工艺
Optimization of Extraction Process of Ruyi Gel Plaster by AHP-CRITIC Combined with Orthogonal Test
刘秋叶 1左亚杰 1何雄 2郑沛 1文玲 1杨俊 1王潇 1文敏1
作者信息
- 1. 湖南中医药大学第一附属医院,湖南 长沙 410000;湖南中医药大学,湖南 长沙 410000
- 2. 湖南省药品审评与不良反应监测中心,湖南 长沙 410000
- 折叠
摘要
目的 优选如意凝胶贴膏提取工艺.方法 以栀子苷含量、黄芩苷含量和干膏得率为评价指标,采用层次分析(AHP)-CRITIC法确定其权重系数;以加水量、浸泡时间、提取时间为考察因素,采用正交试验法优选如意凝胶贴膏的提取工艺,并验证.结果 优选的工艺为第 1 次加 12 倍量水,提取 2.0h;第 2 次加 10 倍量水,提取 1.5h.按最优工艺进行提取,样品的干膏得率、栀子苷含量、黄芩苷含量分别为 24.11%～24.23%、2.20～2.25 mg/g、12.10～12.15 mg/g.结论 优选的提取工艺科学、合理,可为如意凝胶贴膏后续的研发提供依据.
Abstract
Objective To optimize the extraction process of Ruyi Gel Plaster.Methods The geniposide content,baicalin content and dry extract yield were taken as the evaluation indicators,the analytic hierarchy process(AHP)-CRITIC method was used to determine their weight coefficients.The orthogonal test was used to optimize the extraction process of Ruyi Gel Plaster with the water addition amount,soaking time and extraction time as the investigation factors.Then the verification test was carried out.Results The optimal process was as follows:adding 12 times the amount of water for the first time,extracting for 2.0 h;adding 10 times the amount of water for the second time,extracting for 1.5 h.Based on the optimal extraction process,the dry extract yield,geniposide content and baicalin content of the samples were in the range of 24.11%-24.23%,2.20-2.25 mg/g and 12.10-12.15 mg/g,respectively.Conclusion The optimal extraction process is scientific and reasonable,which can provide a basis for the follow-up research and development of Ruyi Gel Plaster.
关键词
如意凝胶贴膏/提取工艺/层次分析法/客观赋权法/干膏得率Key words
Ruyi Gel Plaster/extraction process/analytic hierarchy process/objective weighting method/dry extract yield引用本文复制引用
基金项目
国家中医药管理局中药炮制技术传承基地建设项目([国中医药科技中药便函[2022]59号])
湖南省自然科学基金(2021JJ80066)
湖南省自然科学基金(2023JJ60112)
湖南中医药大学校级科研基金项目(2019XJJJ053)
出版年
2024
国家科技期刊平台
NSTL
万方数据