首页|AHP-CRITIC法结合正交试验法优选如意凝胶贴膏提取工艺

AHP-CRITIC法结合正交试验法优选如意凝胶贴膏提取工艺

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目的 优选如意凝胶贴膏提取工艺.方法 以栀子苷含量、黄芩苷含量和干膏得率为评价指标,采用层次分析(AHP)-CRITIC法确定其权重系数;以加水量、浸泡时间、提取时间为考察因素,采用正交试验法优选如意凝胶贴膏的提取工艺,并验证.结果 优选的工艺为第 1 次加 12 倍量水,提取 2.0h;第 2 次加 10 倍量水,提取 1.5h.按最优工艺进行提取,样品的干膏得率、栀子苷含量、黄芩苷含量分别为 24.11%~24.23%、2.20~2.25 mg/g、12.10~12.15 mg/g.结论 优选的提取工艺科学、合理,可为如意凝胶贴膏后续的研发提供依据.
Optimization of Extraction Process of Ruyi Gel Plaster by AHP-CRITIC Combined with Orthogonal Test
Objective To optimize the extraction process of Ruyi Gel Plaster.Methods The geniposide content,baicalin content and dry extract yield were taken as the evaluation indicators,the analytic hierarchy process(AHP)-CRITIC method was used to determine their weight coefficients.The orthogonal test was used to optimize the extraction process of Ruyi Gel Plaster with the water addition amount,soaking time and extraction time as the investigation factors.Then the verification test was carried out.Results The optimal process was as follows:adding 12 times the amount of water for the first time,extracting for 2.0 h;adding 10 times the amount of water for the second time,extracting for 1.5 h.Based on the optimal extraction process,the dry extract yield,geniposide content and baicalin content of the samples were in the range of 24.11%-24.23%,2.20-2.25 mg/g and 12.10-12.15 mg/g,respectively.Conclusion The optimal extraction process is scientific and reasonable,which can provide a basis for the follow-up research and development of Ruyi Gel Plaster.

Ruyi Gel Plasterextraction processanalytic hierarchy processobjective weighting methoddry extract yield

刘秋叶、左亚杰、何雄、郑沛、文玲、杨俊、王潇、文敏

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湖南中医药大学第一附属医院,湖南 长沙 410000

湖南中医药大学,湖南 长沙 410000

湖南省药品审评与不良反应监测中心,湖南 长沙 410000

如意凝胶贴膏 提取工艺 层次分析法 客观赋权法 干膏得率

国家中医药管理局中药炮制技术传承基地建设项目湖南省自然科学基金湖南省自然科学基金湖南中医药大学校级科研基金项目

[国中医药科技中药便函[2022]59号]2021JJ800662023JJ601122019XJJJ053

2024

中国药业
重庆市食品药品监督管理局

中国药业

CSTPCD
影响因子:1.369
ISSN:1006-4931
年,卷(期):2024.33(16)
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