Clinical Observation of Minocycline Hydrochloride Ointment Combined with Pulp-Opening Decompression and Drainage Surgery in the Treatment of Pulpitis
Objective To investigate the clinical efficacy of Minocycline Hydrochloride Ointment combined with pulp-opening decompression and drainage surgery in the treatment of pulpitis,and its effect on the inflammatory factor levels in gingival crevicular fluid of patients.Methods A total of 98 patients with pulpitis admitted to the hospital from June 2020 to July 2022 were selected and divided into the control group and the observation group by the random number table method,with 49 cases in each group.The patients in the two groups were treated with pulp-opening decompression and drainage surgery,the patients in the observation group were injected with Minocycline Hydrochloride Ointment into the periodontal pocket before sealing with dental gum.Results The total effective rate in the observation group was 91.84%,which was significantly higher than 71.43%in the control group(P<0.05).After treatment,the matrix metalloproteinase(MMP)-9,MMP-8,interleukin(IL)-1β and IL-8 levels in the two groups significantly decreased;the periodontal pocket depth significantly shallowed,the score of tooth looseness significantly decreased;the score of the Visual Analogue Scale significantly decreased;the above indexes in the observation group were significantly better than those in the control group(P<0.05).The pain relief time in the observation group was significantly shorter than that in the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Minocycline Hydrochloride Ointment combined with pulp-opening decompression and drainage surgery can decrease the inflammatory factor levels in gingival crevicular fluid,improve periodontal pocket depth and tooth looseness,and relieve pain in patients with pulpitis.
Minocycline Hydrochloride Ointmentpulp-opening decompression and drainage surgerypulpitisinflammatory factorclinical efficacy
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