Severe Thrombocytopenia Induced by Low Molecular Weight Heparin Calcium Combined with Piperacillin Sodium and Tazobactam Sodium:A Case Report
Objective To provide a reference for the safe use of low molecular weight heparin calcium and piperacillin sodium and tazobactam sodium in clinical practice.Methods The treatment process of an elderly male patient with diabetes foot suffering from severe thrombocytopenia induced by low molecular weight heparin calcium combined with piperacillin sodium and tazobactam sodium admitted to the Bozhou Hospital of Traditional Chinese Medicine was analyzed retrospectively.Results The patient was admitted to the hospital due to the right foot ulceration for one month,with a high platelet count(PLT)of 571×109/L at admission.He was given Piperacillin Sodium and Tazobactam Sodium for Injection(4.5 g,intravenous drip,once every 8 h)and Low Molecular Weight Heparin Calcium Injection(4000 AⅩaIU,subcutaneous injection)based on urine bacterial culture and drug sensitivity test while receiving routine insulin to lower blood glucose.After 12 d of treatment,the patient's PLT decreased to 14×109/L(severe thrombocytopenia),which might be related to the combination of the above two drugs.After discontinuing the two drugs for 4 d,his PLT increased to 52×109/L,and returned to normal after 6 d.Conclusion When using low molecular weight heparin calcium combined with piperacillin sodium and tazobactam sodium in clinical practice,it should be considered that this may lead to severe thrombocytopenia.The patients'blood routine and clinical manifestations should be closely monitored,and the adverse drug reaction should be promptly treated.
piperacillin sodium and tazobactam sodiumlow molecular weight heparin calciumcombination medicationthrombocytopeniadiabetes footmedication safetypharmaceutical care
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