Objective To compare the effects of different pore-forming agents and their dosages on the in vitro release of Morphine Hydrochloride Osmotic Pump Tablets.Methods The tablet cores were prepared with the wet granulation method and coated with semi-permeable film.The effects of different pore-forming agents and their dosages in the semi-permeable film on the in vitro release of Morphine Hydrochloride Osmotic Pump Tablets were compared.Results Different pore-forming agents had a promoting effect on the dissolution of Morphine Hydrochloride Osmotic Pump Tablets.The in vitro release rate of Morphine Hydrochloride Osmotic Pump Tablets increased with the increase in the dosage of pore-forming agents.The effect of the same dosage of pore-forming agent on the in vitro release rate of Morphine Hydrochloride Osmotic Pump Tablets was in the order of polyethylene glycol 6000＞polyethylene glycol 4000＞polyethylene glycol 400＞polyvinyl pyrrolidone K30＞hydroxypropyl cellulose.Conclusion There are significant differences in the effects of different pore-forming agents and their dosages on the release rate of Morphine Hydrochloride Osmotic Pump Tablets.In this study,polyethylene glycol 400 is selected as the preferred pore-forming agent with good release effect and good repeatability.
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