Clinical Observation of Less Invasive Surfactant Administration Technology Combined with Caffeine in the Treatment of Neonatal Respiratory Distress Syndrome
Objective To investigate the clinical efficacy of less invasive surfactant administration(LISA)technology combined with caffeine in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 140 children with NRDS admitted to the Dingzhou City People's Hospital from October 2020 to October 2022 were selected and divided into the control group and the observation group by the random number table method,with 70 cases in each group.The children in the two groups were treated with caffeine,and on this basis,the children in the observation group was treated with LISA technology injected with Poractant Alfa Injection.The clinical efficacy between the two groups was compared.Results The total effective rate in the observation group was 91.43％,which was significantly higher than 75.71％in the control group(P＜0.05).After treatment,the levels of blood oxygen partial pressure of oxygen(PaO2),blood oxygen saturation(SpO2),and oxygenation index(OI)in the observation group were significantly higher than those in the control group(P＜0.05),while the level of blood partial pressure of carbon dioxide(PaCO2)in the observation group was significantly lower than that in the control group(P＜0.05).The cortical oxygen saturation(ScO2),cerebral oxygen quantification index(Cox),and cerebral oxygen metabolism rate(CMRO2)in the observation group were significantly higher than those in the control group(P＜0.05).The levels of Clara cell secreted protein(CC16),transforming growth factor-β,(TGF-β 1),and pulmonary surfactant-related protein A(SP-A)in the observation group were significantly lower than those in the control group(P＜0.05).The incidence of complications in the observation group was 7.14％,which was significantly lower than 21.43％in the control group(P＜0.05).Conclusion LISA technology combined with caffeine injection in the treatment of NRDS has good efficacy and safety,which can improve the blood gas and brain metabolic indicators of children,and inhibit inflammatory reactions.
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维普
