Effect of Butorphanol Injection on Stress Response,Emergence Agitation,and Serum-Related Factor Levels in Children After Tonsillectomy
Objective To investigate the effect of Butorphanol Injection on stress response,emergence agitation,and serum dopamine(DA),substance P(SP),and prostaglandin E2 levels in children after tonsillectomy.Methods A total of 120 children who underwent tonsillectomy in the hospital from June 2021 to June 2023 were selected and randomly divided into the experimental group and the control group,60 cases in each group.The children in the control group were given routine anesthesia,and the children in the experimental group were given butorphanol on the basis of the control group.Results The levels of stress mediators interleukin-6,cortisol,and norepinephrine after surgery in the two groups were significantly higher than those before surgery,and those in the control group were significantly higher than those in the experimental group(P＜0.05).The adrenal cortex hormone(ACTH)level after surgery in the control group was significantly higher than that before surgery(P＜0.05),while that in the experimental group was significantly lower than that before surgery(P＜0.05).The recovery time and post-anesthesia care unit(PACU)residence time in the experimental group were significantly shorter than those in the control group(P＜0.05),while the Ramsay sedation score in the experimental group was significantly higher than that in the control group(P＜0.05).The levels of serum DA and SP after surgery in the two groups were significantly lower than those before surgery(P＜0.05),and those in the experimental group were significantly higher than those in the control group(P＜0.05).The level of serum prostaglandin E2 in the experimental group was significantly lower than that in the control group after surgery(P＜0.05).The total incidence of agitation in the experimental group was 23.33％,wihch was significantly lower than 46.67％in the control group(P＜0.05).The incidence of adverse reactions in the experimental group was 10.00％,which was significantly lower than 25.00％in the control group(P＜0.05).Conclusion Butorphanol Injection can significantly reduce the stress response of children undergoing tonsillectomy,shorten the recovery time of postoperative anesthesia,enhance the sedative effect,reduce the incidence of emergence agitation,and it has good safety.
butorphanoltonsillectomy in childrenstress responseemergence agitationanesthesia effect
万方数据
维普
