Absorption of Six Ginsenosides in Three Forms of Panacis Quinquefolii Radix in Rats
Objective To compare the absorption of six ginsenosides in three forms of Panacis Quinquefolii Radix in rats.Methods With six ginsenosides(ginsenosides Re,Rb1,Rc,Rb2,Rb3,Rd)in traditional decoction pieces,crude powder,and wall-breaking decoction pieces of Panacis Quinquefolii Radix as the investigation indicators,the blood concentrations of six ginsenosides in rat serum were determined by the high-performance liquid chromatography-charged aerosol detector(HPLC-CAD)method.The pharmacokinetic parameters were obtained by fitting with the DAS 2.0 software.The absorption differences of six ginsenosides in three forms of Panacis Quinquefolii Radix in rats were compared.Results Compared with those in the traditional decoction pieces and crude powder,the peak concentration and area under the blood concentration-time curve of the six ginsenosides in the wall-breaking decoction pieces of Panacis Quinquefolii Radix were better(P<0.05),the half-life was longer,the time to peak was shorter,and the bioavailability was higher.The comprehensive evaluation of wall-breaking decoction pieces was the best,followed by the crude powder and traditional decoction pieces.Conclusion Compared with those in the traditional decoction pieces and crude powder,the elimination rate of six ginsenosides in the wall-breaking decoction pieces of Panacis Quinquefolii Radix at the equal dose in rats is lower and the relative bioavailability is higher.
万方数据
维普
