Efficacy Observation of Huoxue Huayu Formula and Mifepristone Combined with Laparoscopic Surgery in the Treatment of Endometriosis
Objective To investigate the clinical efficacy of Huoxue Huayu Formula and mifepristone combined with laparoscopic surgery in the treatment of endometriosis(EMT).Methods A total of 80 patients with EMT admitted to the Chongqing Traditional Chinese Medicine Hospital from March 2021 to March 2022 were selected and randomly divided into the control group and the observation group,with 40 patients in each group.The patients in the two groups underwent laparoscopic surgery and took oral Mifepristone Tablets on the first day of menstruation after surgery,on this basis,the patients in the observation group received Huoxue Huayu Formula.Both groups were treated for two courses with three months as one course.Results The total effective rate in the observation group was 90.00%,which was significantly higher than 72.50%in the control group(P<0.05).After treatment,the pelvic mass volume,dysmenorrhea score,whole blood viscosity at low-,medium-and high-shear rates,plasma viscosity,erythrocyte aggregation index,resistance index(RI)of uterine artery and its branches,pulsatility index(PI),maximum end-systolic blood flow velocity(S)/maximum end-diastolic blood flow velocity(D),serum estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)levels,serum vascular endothelial growth factor(VEGF),angiopoietin-2(Ang-2)and tyrosine protein kinase receptor 2(Tie-2)levels in the two groups significantly decreased(P<0.05).The above indexes in the observation group were significantly better(P<0.05).After treatment,there was no significant change in the blood urea nitrogen(BUN),creatinine(Cr)and alanine aminotransferase(ALT)levels in both groups(P>0.05).The incidence of adverse reactions in the observation group was 10.00%,which was significantly lower than 25.00%in the control group(P<0.05).Conclusion Huoxue Huayu Formula and mifepristone combined with laparoscopic surgery can improve the clinical symptoms and uterine blood circulation of patients with EMT,and inhibit the progression of EMT lesions by regulating the sex hormones and angiogenesis regulatory factor levels in the body.
万方数据
维普
