Objective To investigate the clinical efficacy of Shaofu Zhuyu Decoction in the adjuvant treatment of uterine fibroids of Qi-stagnation and blood-stasis syndrome.Methods Ninety patients with uterine fibroids of Qi-stagnation and blood-stasis syndrome admitted to the Zhangjiakou Hospital of Traditional Chinese Medicine from October 2021 to November 2022 were selected and divided into the control group(44 cases)and the observation group(46 cases)according to different treatment regimens.The patients in the two groups were given oral Mifepristone Tablets,on this basis,the patients in the observation group were given Shaofu Zhuyu Decoction.Both groups received continuous treatment for one month.Results Compared with those in the control group,the traditional Chinese medicine(TCM)syndrome score in the observation group significantly decreased after treatment;the volumes of the uterus and uterine fibroids significantly decreased;the follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),progesterone(P),and testosterone(T)levels significantly decreased;the vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2)levels significantly decreased,the tissue inhibitor of metalloproteinase-2(TIMP-2)level significantly increased,the MMP-2/TIMP-2 significantly decreased(P<0.05).Conclusion The adjuvant treatment of Shaofu Zhuyu Decoction can significantly decrease the volumes of uterus and uterine fibroids,regulate sex hormone levels,decrease the MMP-2/TIMP-2,and improve the ovarian function in patients with uterine fibroids of Qi-stagnation and blood-stasis syndrome.
关键词
少腹逐瘀汤/气滞血瘀型/子宫肌瘤/辅助治疗/性激素
Key words
Shaofu Zhuyu Decoction/Qi-stagnation and blood-stasis syndrome/uterine fibroid/adjuvant treatment/sex hormone
维普
万方数据