Clinical Observation of Low Molecular Weight Heparin Combined with Azithromycin in the Treatment of Severe Mycoplasma Pneumoniae Pneumonia Complicated with Pleural Effusion
Objective lo investigate the clinical efficacy of low molecular weight heparin combined with azithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia(MPP)complicated with pleural effusion.Methods A total of 80 children with severe MPP complicated with pleural effusion admitted to the hospital from January 2022 to June 2023 were selected and randomly divided into the observation group and the control group by the random number table method,with 40 cases in each group.The children in the two groups were treated with azithromycin,on this basis,the children in the observation group received low molecular weight heparin.Results After treatment,the disappearance time of cough,disappearance time of fever,disappearance time of pleural effusion and disappearance time of pulmonary rales,and length of hospital stay in the observation group were significantly shorter than those in the control group group(P＜0.05).The forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and FEV,/FVC in the observation group were significantly higher than those in the control group(P＜0.05);the levels of interleukin-8,interferon y,and tumor necrosis factor-a in the observation group were significantly lower than those in the control group(P＜0.05),the 4 receptor(CD4+)and antigen differentiation cluster 8 receptor(CD8+)/CD4+in the observation group were significantly higher than those in the control group,while the antigen differentiation cluster the observation group was significantly lower than that in the control group(P＜0.05);the platelet count and fibrinogen in the observation group were significantly higher than those in the control group(P＜0.05),while the prothrombin time and activated-partial thromboplastin time in the observation group were significantly shorter than those in the control group(P＜0.05).The liver and kidney function in the observation group and the control group were normal,and the incidence of adverse reactions in the two groups was comparable(27.50％vs.12.50％,P＞0.05).Conclusion Low molecular weight heparin combined with azithromycin in the treatment of severe MPP complicated with pleural effusion can effectively improve the clinical symptoms,signs,lung function,serum inflammatory factor levels,immune function,coagulation function indicators,shorten the length of hospital stay,and have good safety.
low molecular weight heparinazithromycinMycoplasma pneumoniae pneumoniapleural effusionlung function
万方数据
维普
