Current Status of Microbial Contamination in Cosmetics at Home and Abroad and the Construction of Preservative System
Objective To provide a reference for the construction of a cosmetic preservative system in China.Methods The current status of microbial contamination in cosmetics at home and abroad and its influencing factors were analyzed,and the construction ideas of cosmetic preservative system were explored.Results The microbial contamination in cosmetics at home and abroad mainly involved the total count of aerobic bacteria,total count of molds and yeasts.Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli were more common in foreign countries,while no pathogenic bacterium had been found in China.The influencing factors of microbial contamination in cosmetics included product design and formula optimization.The first-level barrier was built based on hazard analysis critical control point(HACCP)system,and the second-level barrier was built based on physical and chemical factors,which jointly formed a domestic cosmetic preservative system.Conclusion When designing cosmetic formulas,the packaging system,water activity,pH,dosage form,preservatives,functional components and other factors can be considered comprehensively to form a preservative system,which can decrease the amount of preservatives,lower the risk of cosmetic contact allergic dermatitis induced by a single fence factor of preservatives,and improve the overall preservative efficacy of cosmetics.
cosmeticmicrobial contaminationpreservativepreservative systempreservative efficacyfence theory
万方数据
维普
