Objective To establish an anion exchange chromatography method for simultaneous determination of sodium lactate and total chlorine contents in Sodium Lactate Ringer's Injection.Methods The analytical column was Dionex IonPacTM AS11-HC column(250 mm×4 mm),the protective column was AS11-HC column(50 mm×4 mm),the eluent was 10 mmol/L potassium hydroxide solution,the flow rate was 1.0 mL/min,the detector temperature was 35℃,the column temperature was 30℃,the electrical conductivity detector was adopted,the suppressor suppression current was 25 mA,and the injection volume was 25 μL.Results The linear ranges of lactate ion and chloridion were 9.97-249.37 μg/mL,15.27-381.70 μg/mL(r=0.999 7,1.000 0,n=6)respectively.The RSDs of precision,stability and repeatability tests were all lower than 2.0%.The average recovery rates of llactate ion and chloridion were 100.74%,100.48%,with the RSDs of 1.17%,1.53%(n=9)respectively.Conclusion The established method is easy,sensitive,stable and accurate,which can be used to determine the contents of sodium lactate and total chlorine in Sodium Lactate Ringer's Injection.
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