Objective To investigate the clinical efficacy of probiotics combined with specific immunotherapy in the treatment of children with dust mite-induced allergic asthma.Methods A total of 104 children with dust mite-induced allergic asthma admitted to the hospital from April 2022 to April 2023 were selected and randomly divided into the control group and the observation group by the random number table method,with 52 cases in each group.The children in the two groups received routine symptomatic treatment and specific immunotherapy[subcutaneous injection of Mites Allergens ALK(503)D.p],on this basis,the children in the observation group received oral Live Combined Bifidobacterium and Lactobacillus Tablets.All children were treated continuously for six months.Results The total effective rate in the observation group was 96.15%,which was slightly higher than 92.31%in the control group(P>0.05).After treatment,the percentage of peak expiratory flow to predicted value(PEF%)and the percentage of forced expiratory volume in one second to predicted value(FEV1%)in the two groups significantly increased,and the fractional exhaled nitric oxide(FeNO)level significantly decreased(P<0.05);the interleukin-6(IL-6)and interleukin-17(IL-17)levels significantly decreased,and the interleukin-10(IL-10)level significantly increased(P<0.05);the interferon-γ(IFN-γ)level significantly increased,and the interleukin-4(IL-4)level significantly decreased(P<0.05);the airway resistance(Raw),peak airway pressure(PIP)and work of breath(WOB)significantly decreased,and the dynamic lung compliance(Cdyn)significantly increased(P<0.05);the integrin α4β1,integrin αvβ6,vascular cell adhesion molecule-1(VCAM-1),and intercellular cell adhesion molecule-1(ICAM-1)levels significantly decreased(P<0.05);the count of Escherichia coli decreased significantly,the counts of Lactobacillus and Bifidobacterium significantly increased(P<0.05);and those in the observation group were significantly better than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Probiotics combined with specific immunotherapy can improve the immune function,lung function,and respiratory function of children with dust mite-induced allergic asthma,which may be related to the regulation of T helper cell(Th)17/regulatory T cells(Treg),Th1/Th2 and intestinal flora.
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