Prognosis of Temozolomide Combined with Gamma Knife Stereotactic Radiotherapy in the Treatment of High-Grade Gliomas and Influencing Factors of Postoperative Residual Recurrence
Objective To investigate the prognosis of temozolomide combined with Gamma Knife stereotactic radiotherapy in the treatment of postoperative residues of high-grade gliomas,and to analyze its influencing factors.Methods A total of 117 patients with postoperative residues of high-grade gliomas admitted to the hospital from January 2021 to January 2023 were selected and divided into the control group(54 cases)and the observation group(63 cases)according to different treatment regimens.The patients in the two groups underwent Gamma Knife stereotactic radiotherapy,and then received dehydration treatment for 3-5 d,on this basis,the patients in the observation group received Temozolomide Capsules orally for two cycles.The clinical efficacy,incidence of adverse reactions and postoperative residual recurrence between the two groups were compared.The univariate analysis and binary Logistic regression analysis were used to identify the independent risk factors for postoperative residual recurrence in patients receiving combined therapy.Results The total effective rate in the observation group was 73.02%,which was significantly higher than 48.15%in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(55.56%vs.64.81%,P>0.05).The postoperative residual recurrence rate in the observation group was 22.22%,which was significantly lower than 40.74%in the control group(P<0.05).Patients' age(≥60 years),tumor diameter(≥5 cm)and incomplete resection therapy were the independent risk factors for postoperative residual recurrence(P<0.05).Conclusion Temozolomide combined with Gamma Knife stereotactic radiotherapy in the treatment of high-grade gliomas can further improve the efficacy and decrease the risk of postoperative residual recurrence.Patients' age(≥60 years),tumor diameter(≥5 cm)and incomplete resection therapy are the independent risk factors for postoperative residual recurrence in patients.
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