Risk Analysis of Renal-Related Adverse Events Induced by Antihypertensive Drugs
Objective To provide a reference for the rational and safe use of antihypertensive drugs in clinical practice.Methods The renal-related adverse drug events(ADEs)reports induced by antihypertensive drugs in the FDA Adverse Event Reporting System(FAERS)from January 2016 to December 2023 were extracted by the OpenVigil 2.1 platform.The ADEs were described by the preferred term in the Medical Dictionary for Regulatory Activities(MedDRA 27.0).The relevant signals were mined by the reporting odds ratio and proportional reporting ratio methods.Results A total of 10 494 cases of reports were included,among which there were 8 159,1 727,466,109,53 cases of hypokalemia,renal dysfunction,gouty arthritis,gouty crystal deposition,uric acid-induced kidney damage respectively,with 66,43,27,eight,six positive signals detected respectively;the cases of ADEs in males was more than those in females,except for uric acid-induced kidney damage,the patients aged≥41 years was the most,and the United States was the country that reported the most ADEs.A total of 42 antihypertensive drugs showed positive signals of renal dysfunction,involving diuretics,α-receptor antagonists,β-receptor antagonists,calcium channel blockers,angiotensin-converting enzyme inhibitors,angiotensin Ⅱ receptor blockers,renin inhibitors and compound preparations.Eight antihypertensive drugs showed positive signals of gouty arthritis and gouty crystal deposition,involving diuretics,α-receptor antagonists,β-receptor antagonists,angiotensin-converting enzyme inhibitors and vasodilators.There were 18 drugs with≥three ADR signals,and the adverse outcomes induced by the drugs were basically similar.Conclusion Multiple antihypertensive drugs can induce the renal-related ADEs.During the antihypertensive therapy,it is necessary to closely monitor the risks of renal dysfunction,hypokalemia,gouty arthritis,gouty crystal deposition and uric acid-induced kidney damage,especially paying attention to the antihypertensive drugs inducing multiple ADEs.
antihypertensive drugrenal dysfunctiongoutadverse drug eventsignal miningreporting odds ratioproportional reporting ratioFDA Adverse Event Reporting System
万方数据
维普
