Effectiveness Analysis of Antibiotic Rotation Therapy in Controlling the Antibiotics Use Density in the DIP Mode
Objective To investigate the effectiveness of antibiotic rotation therapy in controlling the antibiotics use density(AUD)in the diffuse panbronchiolitis(DIP)mode.Methods A retrospective analysis was conducted on the clinical data of 1 138 patients underwent operation for appendicitis admitted to the hospital from January 2022 to June 2023.Patients admitted from January to August 2022(before antibiotic rotation in DIP mode)were selected as the group A(596 cases),and patients admitted from September 2022 to June 2023(after antibiotic rotation in DIP mode)were selected as the group B(542 cases).The clinical efficacy,white blood cell count(WBC),serum amyloid A protein(SA A),interleukin-6(IL-6),recovery time of bowel sound,exhaust time,defecation time,incidence of postoperative adverse events,cumulative defined daily dose(DDD)of antibiotics,composition of antibiotics use,cumulative number of infusion bags of antibiotics,cost of antibiotics,and AUD were compared between the two groups.Results There was no significant difference in clinical efficacy,WBC,SAA,IL-6,the recovery time of bowel sound,exhaust time,defecation time,and incidence of postoperative adverse events between the two groups(P＞0.05).The cumulative DDD of antibiotics,use rate of antibiotics alone,cumulative number of infusion bags of antibiotics,antibiotic cost,and AUD in the group B were significantly better than those in the group A(P＜0.05).Conclusion Antibiotic rotation based on DIP mode has a certain control effect on the AUD without affecting overall efficacy,and can reduce the cost of patients and the output of medical waste.
DIP modeantibiotic rotationantibiotics use densityeffectiveness
万方数据
维普
