Preparation and in Vitro Release Study of Folic Acid-Chitosan Modified Piperine Nanostructured Lipid Carriers
Objective To prepare folic acid-chitosan modified piperine nanostructured lipid carrier(FA-CS-PIP-NLC),and to evaluate its in vitro release properties.Methods Folic acid-chitosan complex(FA-CS)was prepared by reacting and purifying folic acid with chitosan.Piperine was used as a model drug to prepare piperine nanostructured lipid carrier(PIP-NLC)by solvent injection method.FA-CS-PPI-NLC was prepared by the charge adsorption method,and its morphological characteristics,particle size,dispersion coefficient,Zeta potential,encapsulation efficiency,drug loading capacity,and in vitro release characteristics in different pH release media were investigated.Results The prepared FA-CS-PPI-NLC was spherical or nearly spherical,with a particle size of(130.6±3.7)nm,a dispersion coefficient of 0.26±0.01,a Zeta potential of(2.9±1.2)mV,an encapsulation efficiency of(89.63±2.07)％,and a drug loading capacity of(1.28±0.33)％.The cumulative release rates of FA-CS-PIP-NLC in phosphate buffer solutions(pH 7.4 and pH 5.5)release medium for 48 h were 65.42％and 69.73％,respectively.Conclusion The prepared FA-CS-PPI-NLC has a small particle size,good stability,high encapsulation efficiency,and good sustained release properties.
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维普
