Preparation and Pharmaceutial Evaluation of Film Spraying Agent of Lavender Essential Oil
Objective To establish the prepare process of film spraying agent of lavender essential oil,and to evaluate its pharmaceutical.Methods With extraction time,ethanol volume fraction,and ethanol dosage as investigation factors,and with dry paste rate,free total anthraquinone content,and resveratrol content as evaluation indicators,the L9(33)orthogonal test was used to optimize the extraction process of Rhei Radix et Rhizoma and Angelicae Dahuricae Radix.The extract was mixed and then spray dried.The film-forming material of the spray agent,ethanol volume fraction,and the dissolving mode of the medicinal power were screened through the single factor test to prepare the film spraying agent of lavender essential oil.The in vitro antibacterial test of the prepared film spraying agent of lavender essential oil was conducted.The mouse burn model was established to evaluate its pharmacodynamics.Results The optimal extraction process of Rhei Radix et Rhizoma and Angelicae Dahuricae Radix was to extract with 10 times of 60％ethanol twice,each time for 2 h,and spray-dry the extract at 120 ℃ after mixing.The results of the single factor test showed that 3％hydroxypropyl methyl cellulose(HPMC)was selected as film-forming material,80％ethanol was selected as solvent.The powder,lavender essential oil and four-needle zinc oxide whisker compound were directly added to the swollen film material,and then the solvent was supplemented to form the film spraying agent.The results of antibacterial experiment showed that the bacteriostatic circle of the film spraying agent of lavender essential oil on Staphylococcus aureus and Escherichia coli was 8-12 mm,with a good antibacterial effect.The results of the pharmaceutical evaluation showed that film spraying agent of lavender essential oil could accelerate the healing of burns.Conclusion Film spraying agent of lavender essential oil with a good antibacterial effect and promoting the repair of scalded skin was successfully prepared.
万方数据
维普
