Clinical Observation of Levetiracetam Combined with Sodium Valproate in the Treatment of Elderly Patients with Focal Epilepsy
Objective To investigate the clinical efficacy of levetiracetam combined with sodium valproate in the treatment of elderly patients with focal epilepsy(FE),and its effects on patients'electroencephalogram,neurological,and cognitive functions.Methods A total of 110 elderly patients with FE admitted to the hospital from January 2020 to December 2022 were selected and divided into the control group and the observation group by the random number table method,with 55 cases in each group.The patients in the two groups were treated with Sustained-Release Sodium Valproate Tablets,while the patients in the observation group were additionally treated with Levetiracetam Tablets.Both groups were treated for six months.Results The total effective rate in the observation group was 83.64％,which was significantly higher than 65.45％in the control group(P＜0.05).After treatment,the frequency of epileptic seizures,duration of seizures,δ and θ frequency band power of electroencephalography,and serum neuron-specific enolase(NSE)level in the observation group were significantly lower than those in the control group(P＜0.05),while the Mini-Mental State Examination(MMSE)score,α and β frequency band power of electroencephalography,and serum brain-derived neurotrophic factor(BDNF)level in the observation group were significantly higher than those in the control group(P＜0.05).The incidence of adverse reactions between the observation group and the control group was comparable(30.91％vs.23.64％,P＞0.05).Conclusion Levetiracetam combined with sodium valproate has good clinical efficacy and safety in the treatment of elderly patients with FE,which can effectively control epileptic seizures,improve electroencephalography,reduce neurological damage,and enhance cognitive function.
focal epilepsylevetiracetamelectroencephalogramcognitive function
万方数据
维普
