Effect of Eleutheroside B on the Learning and Memory Ability of Rats with Rapid Eye Movement Sleep Deprivation
Objective To investigate the effect of eleutheroside B on the learning and memory ability of rats with rapid eye movement sleep deprivation(REMSD).Methods REMSD model rats were constructed by the modified multi-platform water environment method.The rats were divided into two groups,each of which was further divided into the control group(equal volume of distilled water),the model group(equal volume of distilled water),the high-,medium-and low-dose(eleutheroside B)groups(80,40,20 mg/kg).Rats in each group were given drugs or distilled water by gavage once a day for 7 d.Learning and memory training,consolidation training and testing were conducted by a hexagonal maze box during modeling,the search time and error frequency were recorded,the search frequency and cognitive rate were calculated.Results In terms of learning and memory acquisition,compared with those in the model group,the search time significantly shortened,the error frequency significantly decreased,and the cognitive rate significantly increased in the high-and medium-dose groups(P＜0.05);in terms of learning and memory consolidation,compared with those in the model group,the above indicators significantly improved in the high-,medium-and low-dose groups(P＜0.05).Conclusion Eleutheroside B has a certain improvement effect on the learning and memory disorders in REMSD rats.
eleutheroside Brapid eye movementsleep deprivationlearning and memoryrat
万方数据
维普
