Correlation of Dapagliflozin Plasma Concentration with UGT1A9 Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus
Objective To investigate the correlation of dapagliflozin plasma concentration with the polymorphisms of uridine diphosphate-glucuronosyltransferase(UGT)1A9 gene in patients with type 2 diabetes mellitus(T2DM).Methods A total of 30 patients with T2DM treated with dapagliflozin in the hospital from March to June 2021 were selected.After at least 3 d of medication,the steady-state dapagliflozin plasma concentration was determined by the liquid chromatography-tandem mass spectrometry,the UGT1A9 genotype was sequenced by the sequencing method,and the differences in dapagliflozin plasma concentration among patients with different genotypes were compared.Results Four UGT1A9 gene mutation sites including rs234681098,rs234681543,rs234681426 and rs234681645 were detected.The average steady-state dapagliflozin plasma concentration in 30 patients was(10.62±6.18)ng/mL;there was no significant difference in the dapagliflozin plasma concentration among patients with different genotypes(P＞0.05).Conclusion Mutations at rs234681098,rs234681543,rs234681426 and rs234681645 in UGT1A9 do not affect the dapagliflozin plasma concentration in patients with T2DM.
万方数据
维普
