Effect of Hydromorphone Preemptive Analgesia Combined with Transversus Abdominis Plane Block in Laparoscopic Myomectomy
Objective To investigate the effects of hydromorphone preemptive analgesia combined with ultrasound-guided transversus abdominis plane block(TAPB)on the perioperative stress response and postoperative analgesia in patients undergoing laparoscopic myomectomy.Methods A total of 62 patients planned to undergo laparoscopic myomectomy in the hospital from August 1,2022 to August 31,2023 were selected and randomly divided into the control group(32 cases)and the observation group(30 cases).The patients in the two groups underwent TAPB after anesthesia induction;the patients in the observation group received intravenous injection of 20 μg/kg of Hydromorphone Hydrochloride Injection for preemptive analgesia 15 min before surgery,while the patients in the control group received the same volume of 0.9％Sodium Chloride Injection by the same method.Results Compared with those in the control group,the serum epinephrine(E)and norepinephrine(NE)levels in the observation group significantly decreased immediately after extubation and at 6 h after surgery,the Visual Analog Scale(VAS)scores significantly decreased at 2 h and 6 h after surgery;the dosage of sufentanil and the frequency of patient-controlled analgesia significantly decreased at 24 h after surgery;the dosage of remifentanil used during surgery significantly decreased(P＜0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P＞0.05).Conclusion Compared with the single application of TAPB,hydromorphone preemptive analgesia combined with TAPB can significantly alleviate the stress response of patients undergoing laparoscopic myomectomy,decrease the dosage of opioids,and have better postoperative analgesic effects.
万方数据
维普
