Oxidative stress refers to a mechanism in which the body produces a large amount of reactive oxygen species after being stimulated by external factors,leading to cellular oxidative damage.It is closely related to the occurrence and development of various dis-eases such as cardiovascular diseases,neurological diseases,inflammatory diseases,and tumors.Therefore,to find effective antioxi-dants has become one of the important ways for disease prevention and treatment.Dioscin is a natural compound with antioxidant and anti-inflammatory effects.In recent years,studies have found that dioscin plays an important role in antioxidant stress.This review pro-vides an overview of the concept and mechanism of oxidative stress,and discusses its possible mechanisms of action.Dioscin can increase the production and release of endogenous antioxidants in the body by clearing free radicals and peroxides,inhibiting the activa-tion of oxidative stress signaling pathways such as Nrf2-ARE pathway,NF-KB pathway,MAPK pathway,Keap1-Nrf2 pathway,and AMPK pathway.This study summarizes the research progress on the antioxidant stress mechanism of dioscin,so as to provide reference for subsequent research.
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