Research Progress on the Clinical Three-Dimensional Mechanism of Active Ingredients of Gouteng
Gouteng is an evergreen vine belonging to the Rubiaceae family.Gouteng plays an important role in the treatment of heart and liver related diseases,but its specific mechanism of action is not yet clear.Gouteng is a very important traditional Chinese medicine in the treatment of traditional Chinese medicine.It has the effects of calming the liver,extinguishing wind,clearing heat,and calming shock.It plays an important role in various diseases such as insomnia,cardiovascular and cerebrovascular systems,and digestive sys-tems.Rhynchophylline(RIN)and Isorhynchophylline(IRN)are two important alkaloids in the active ingredients of gouteng.Based on the pharmacological characteristics of RIN and IRN,the results of experimental studies on the active components of gouteng and the lit-erature were reviewed,it was found that the mechanism of action of gouteng is related to autophagy of RIN and IRN cells.Based on the pharmacological characteristics of gouteng and gastrodia elata,the clinical application and mechanism of action of gouteng tomentosa combined with gastrodia elata were summarized,the combination of RIN,IRN and gastrodia elata can increase the bioavailability of liver cells.This study provide reference and train of thought for the study of the clinical effects of traditional Chinese medicine,the exploration of the effective components of traditional Chinese medicine,and the discovery of new therapeutic methods of traditional Chinese medicine.