Two Cases of Drug Eruption Suspected Induced by Modified Euthyrox
Euthyrox is an artificially synthesized exogenous levothyroxine,similar in composition to the naturally secreted tetraiodothy-ronine of the thyroid gland.It can be converted into free triiodothyronine in peripheral organs and further binds to receptors to regulate thyroid function.The two patients reported in our hospital are both young women with no previous history of drug or food allergies,and no family genetic history.After admission,a thyroidectomy was performed,and after the surgery,regular administration of euthyrox was given to prevent recurrence of goiter,and the same batch and manufacturer of euthyrox were taken.The two patients showed varying degrees of drug-induced rash before and after treatment,which improved after anti allergic treatment.The adverse reactions of both patients were time-dependent with the use of euthyrox,which is considered to be caused by the new excipient mannitol of euthyrox.Com-mon adverse reactions during intravenous drip of mannitol include allergic rash and urticaria.Based on two suspected cases of drug-induced rash caused by euthyrox in our hospital,a comprehensive analysis of the changes in patient related indicators and a retrospective analysis of similar cases at home and abroad were conducted to explore the characteristics and possible mechanisms of drug-induced rash,in order to raise the attention of clinical physicians to this phenomenon and provide some reference for in-depth research on the dis-ease and promoting the safe and rational use of euthyrox.
Modified new drugEuthyroxDrug eruptionAdverse drug reactionsPathological mechanism
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