Expert Consensus on Research and Development Strategie of Therapeutic HPV Vaccine
Human papilloma virus(HPV)is a double-stranded DNA virus that high-risk HPV infection predisposes to the risk of cer-vical cancer and precancerous lesions.More than 400 different HPV subtypes have been identified in recent years,and most HPV infec-tions are asymptomatic and resolve spontaneously.Women with a normal immune system,starting with high-risk HPV infection,usually take 15 to 20 years to develop cervical cancer,but for women with a weaker immune system,such as untreated women living with HIV(WLHIV),cervical cancer may progress more quickly(5 to 10 years).In 2006,prophylactic HPV vaccine was developed and mar-keted,but it has no therapeutic effect on patients who have been infected with HPV or precancerous lesions.The development of thera-peutic HPV vaccine may provide an important complement to the current methods for the prevention and treatment of cervical cancer.therapeutic HPV vaccine is different from prophylactic HPV vaccine,therapeutic HPV vaccine will induce specific cellular rather than humoral immunity(neutralizing antibodies),and be designed to clear or treat existing HPV infections,their associated precancerous lesions and invasive cervical cancer.Therefore,a reasonable therapeutic HPV vaccine development strategy will not only allow the HPV therapeutic vaccine product development enterprises to avoid detours and improve the transformation efficiency,but also benefit patients with HPV infection,related lesions and even cancer as soon as possible.The therapeutic HPV vaccine working group gatherd experts and scholars in the field,referred to related publications,combined with the clinical characteristics and background of HPV,compiled the"Expert Consensus on Research and Development Strategy of Therapeutic HPV Vaccin",which the scope of adaptation and related termi-nology of the compilation was clarified,and the clinical development direction,research population,characteristic and vaccination plan of therapeutic HPV vaccine were emphasised,to accelerate and promote the research and development of therapeutic HPV vaccine.It provides reference for social research and development of therapeutic HPV vaccine products and the formulation of national policies related to therapeutic HPV vaccine.
Human papilloma virus(HPV)Therapeutic HPV vaccineDevelopment strategyExpert consensus
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