Research Progress on Non-Coding RNA Related to Endometriosis
Endometriosis(EMS)is a common benign gynecological disease affecting the health of women of childbearing age,which is characterized by the presence of endometriosis outside the body of the uterus.The clinical manifestations are mainly pelvic pain and infertility,which seriously harm women's health.At present,the main treatment methods of EMS are medicine and surgery.However,there is still a lack of effective treatment,so it has become a common disease that affects the quality of life and fertility of women.The eti-ology of EMS is not clear yet.It is of positive significance to explore the pathogenesis of the disease and search for therapeutic targets.With the rapid development of gene sequencing,the exploration of the etiology of EMS has faced new challenges.Studies have found that epigenetics may be involved in the development of EMS in clinical practice.Non-coding RNA refers to RNA that does not code for pro-teins,including microRNA(miRNA)and long non-coding RNA(lncRNA)etc.At present,the relationship between non-coding RNA and EMS has been preliminarily studied.Abnormal expression of non-coding RNA can promote the development of EMS by promoting angiogenesis,apoptosis,cell proliferation,cell invasion,cell migration,epithelial-mesenchymal transformation,inflammation,and estrogen and progesterone dysregulation.This study reviewed the recent research progress on the expression patterns and action mecha-nisms of some non-coding RNAs in EMS in recent years,and discussed the feasibility of multiple non-coding RNAs as potential biomark-ers and therapeutic targets of EMS,to provide new ideas for the diagnosis and treatment of EMS.
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